Thus, larger studies that aim to evaluate: (1) ETV1 mRNA and protein expression levels; (2) the biological significance of ETV1 function; and (3) the clinical application of ETV1 inhibitors in patients with endogenous CIC-ERF co-deleted tumors (compared to CIC-ERF WT tumors) is warranted in this subset of PCa. Here, ETV1 is linked to posterior cortical atrophy.