In order to explore clinical outcomes of patients harboring CIC-ERF co-deleted tumors, we performed a survival analysis using the aforementioned PCa datasets and observed significantly worse outcomes in patients who harbored the CIC-ERF co-deletion (p=0.001, disease-free survival [DFS] [ERF-CIC co-deletion 25 events/90 total; no ERF-CIC co-deletion 153 events/910 total] and p=0.01, progression-free survival [PFS] [ERF-CIC co-deletion 16 events/52 total; no ERF-CIC co-deletion 77 events/442 total]; Figure 1G). Here, CIC is linked to posterior cortical atrophy.