TMPRSS2 and posterior cortical atrophy: The predominant mode of ETS activation in PCa is through chromosomal rearrangements that fuse ERG, ETV1, ETV4, and ETV5 to the androgen-regulated TMPRSS2 gene, leading to fusion oncoproteins that drive oncogenesis (Clark and Cooper, 2009; Feng et al., 2014; Helgeson et al., 2008; Tomlins et al., 2006; Tomlins et al., 2005).