To explore this, we generated a signature gene set of upregulated genes from our dual CIC and ERF deficient PNT2 cells (ERF KD +CIC KO) and projected the Cancer Genome Atlas PCa (TCGA-PRAD) dataset onto the transcriptional space of these signature gene sets using the ssGSEA module (Version 10.0.9) on GenePattern (Reich et al., 2006). This evidence concerns the gene CIC and posterior cortical atrophy.