Notably, in PCa, CIC is commonly altered through genomic loss (homozygous and heterozygous deletion) in ~10% of PCa patients (Abida et al., 2019; Grasso et al., 2012; Hieronymus et al., 2014; Huang et al., 2017; Robinson et al., 2015; Cancer Genome Atlas Research Network, 2015) and inactivation of CIC de-represses ETV1, ETV4, and ETV5 transcription to promote tumor progression (Bettegowda et al., 2011; Choi et al., 2015; Kim et al., 2018; Okimoto et al., 2017). Here, ETV4 is linked to posterior cortical atrophy.