ERF and posterior cortical atrophy: In order to understand the association between CIC and/or ERF alterations in specific PCa cohorts, we stratified published datasets to identify patients that represent primary PCa (Fraser et al., 2017; Hieronymus et al., 2014; ‘ Cancer Genome Atlas Research Network, 2015) (PNAS 2014, n=272; Cell 2015, n=333; Nature 2017, n=477 primary PCas) and metastatic castrate resistant prostate cancer (mCRPC) (Abida et al., 2019; Grasso et al., 2012; Robinson et al., 2015) (Nature 2012, n=50; Cell 2015, n=150; PNAS 2019, n=429 mCRPCs).