In our work, intravital microscopy, peritoneal lavage analysis, and flow cytometric or immunohistochemical staining of myocardial infarct tissue showed unanimously that loss of platelet P-selectin neither slowed cell recruitment nor protected from myocardial ischemia and reperfusion injury despite a significant reduction in circulating, rolling, and tissue infiltrating PLC. The gene discussed is HSPG2; the disease is myocardial infarction.