Neither LDL-C lowering (38.7 mg/dL) nor the use of PCSK9 inhibitors was associated with the incidence of diabetes, respectively, risk ratio = 1.07 (95%CI 1.03–1.11) and risk ratio = 1.00 (95%CI 0.93–1.07) [58]. This evidence concerns the gene PCSK9 and diabetes mellitus.