EHMT1 and Kleefstra syndrome: Out of the constraint overlapped genes (1086 genes), we shortlisted three genes, one with possible studied pleiotropism of NDDs and CAs: EHMT1, which causes Kleefstra syndrome, known to harbor heterozygous intragenic EHMT1 pathogenic variants from heterozygous deletions at chromosome 9q34.3 (Yatsenko et al. 2009; Willemsen et al. 2012).