A caveat emerged when Dario's group showed that LKB1, in addition to AMPK, also phosphorylated and activated 12 members of the AMPK-related kinase (ARK) family that have kinase domains related to AMPK [80] — any one of these could potentially exert the tumour suppressor effects of LKB1. The gene discussed is PRKAA2; the disease is neoplasm.