NFKB1 and psoriasis: During the inflammatory process, activation of Th1 and Th17 cells via a nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) pathway is triggered by mature plasmacytoid and myeloid dendritic cells, which are migrated into the skin-draining lymph nodes and produce psoriasis relevant mediators of inflammation (Wagner et al., 2010; Mease, 2015; Tang et al., 2021).