For determination of susceptibility to psoriasis by evaluating the deleterious effect of the nsSNPs in TLR4 gene, the results indicated that among the 2 nsSNPs, only the rs1018673641 was predicted to be probably damaging by Polyphen-2 with score of 0.788 (score range: 0-1; sensitivity: 0.85; specificity: 0.93) (Figure 3B). Here, TLR4 is linked to psoriasis.