KL and hypophosphatemia: In the kidneys, it induces the transcription of some genes, such as Klotho (KL), the co-receptor for the FGF-23/FGFR1 signaling; NPT2a and NPT2c, the channels responsible for renal phosphate reabsorption and correction of hypophosphatemia; and TRPV5 and CaBP28k, which increase renal calcium reabsorption.