The reduced sensitivity to OXPHOS inhibition of cancer cells upon NNMT overexpression and DNMT1 knockdown was also reflected by attenuated ATF4 upregulation and p‐S6 downregulation when treated with OXPHOS inhibitors (Gboxin, Oligomycin A, and Berberine) (Figure 4H–J). This evidence concerns the gene DNMT1 and cancer.