However, NNMT inhibition and DNMT1 overexpression are not able to render OXPHOS‐resistant cancer cells (786‐O and CFPAC‐1) sensitive (data not shown), likely because enhanced DNMT1 activity itself is not able to create a genome‐wide DNA methylation status sufficient for altering cancer cells’ sensitivity to OXPHOS inhibition. The gene discussed is NNMT; the disease is cancer.