As shown in Figure 5A–D, expression of NNMT remains low in tumor xenografts driven by OXPHOS inhibition‐sensitive cancer cell lines (NCI‐H82 and MDA‐MB‐453) compared with those driven by the resistant cancer cells (CFPAC‐1 and NCI‐H82‐OE‐NNMT/sh‐DNMT1), while the opposite expression pattern is observed for DNMT1 (Figure 5A–D). Here, DNMT1 is linked to cancer.