The poor prognosis of HNSCC patients after chemotherapy is related to resistance to platinum drugs, the effects of which include the enhancement of DNA damage repair, antioxidative stress, and NF‐κB signaling pathway activation.[44, 45, 46] In this study, SERPINB3 displayed the potential to reverse cisplatin resistance in HNSCC. The gene discussed is SERPINB3; the disease is head and neck squamous cell carcinoma.