The sensitivity of tumors to cisplatin mainly depends on the ability of cisplatin to recognize and repair DNA damage.[35, 36] Based on the discovery and confirmation that SERPINB3 regulates the cisplatin sensitivity of HNSCC through DNA damage repair, we identified USP1, which interacts with SERPINB3, by Co‐IP and mass spectrometry. The gene discussed is SERPINB3; the disease is head and neck squamous cell carcinoma.