As a key protein in HPV‐mediated cancer transformation, E6 can inactivate a number of cellular proteins that contain PDZ domains, such as the tumor suppressor p53,[31] human discs large tumor suppressor,[32] and members of the MAGI family of proteins,[33] which are dependent on the ubiquitin ligase UBE3A/E6AP‐mediated proteasomal degradation pathway.[34] Whether SERPINB3 inhibition after HPV‐E6 induction depends on the ubiquitin‐mediated mechanism above remains unknown. This evidence concerns the gene UBE3A and cancer.