SERPINB3 is a serine protease inhibitor that is highly expressed in a variety of squamous cell carcinomas and exhibits significant antiapoptotic properties.[14, 15] We found that SERPINB3 could be downregulated by the HPV oncoprotein E6 and promote cisplatin sensitivity in HPV‐positive HNSCC by inhibiting DNA damage repair. The gene discussed is SERPINB3; the disease is squamous cell carcinoma.