BCL2 and obesity due to melanocortin 4 receptor deficiency: Gut microbiota (GM) consists of a diverse community of symbiotic bacteria, which affect the health of the host in a number of ways, including through their metabolites.[23] The critical role of GM in metabolic syndrome has been well studied in rodents and humans.[24, 25] Indeed, the gut microbial metabolites can modulate metabolism in multiple tissues, thereby playing key roles in the pathogenesis of obesity, NAFLD, and type 2 diabetes.[26] However, their interaction with the BCL‐2 family proteins was not known.