Obesity is associated with numerous diseases, including cardiovascular disease, nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and certain types of cancer.[1, 2] Obesity‐associated conditions are the leading causes of premature death.[3] In obesity‐associated conditions, NAFLD is a primary and common pathological presentation.[4] Many factors can contribute to obesity and metabolic syndrome,[5] including the BCL‐2 family proteins.[6]. The gene discussed is BCL2; the disease is obesity due to melanocortin 4 receptor deficiency.