Although this overexpression led to noticeable but not statistically significant increase in the level of Srebp1 and Scd1 (Figure S8C), it did not appear to be able to overcome the resistance of the bid−/− mice to obesity (Figure S7D) or to hepatic steatosis (Figure S8E,F) or dyslipidemia (Figure S8G) following HFD feeding, suggesting that CD36 could be a contributing factor to, but not a sufficient cause for, the HFD‐resistant phenotypes of the bid−/− mice, which was also consistent with the context‐dependent effect of CD36 as shown previously.[38, 39, 40]. Here, SREBF1 is linked to obesity due to melanocortin 4 receptor deficiency.