The rate of undecided diagnoses among 12 physicians interpreting multiple diagnostic criteria to diagnose PJI in this study (Table 2) was 23.5% (range: 5.4 to 44.0%), with academic surgeons as a group choosing an undecided diagnosis less frequently than community surgeons or ID specialists (16.2% vs. 29.1%, and 16.2% vs. 25.1%; both p<0.0001). Among 140 cases with a negative result for all five laboratory tests (ESR, CRP, SF-WBC, SF-PMN%, and culture), the mean undecided rate across all physicians was 16.3%. The gene discussed is ESR1; the disease is juvenile polyposis syndrome.