BACE1 and Alzheimer disease: Acacetin extracted from the whole Agastache rugosa plant plays a protective role in AD for downregulating both APP and β-amyloid cleaving enzyme (BACE-1) protein expression, reducing Aβ production, and preventing the eye degeneration and behavioral abnormality in Drosophila melanogaster AD model by mediating the transcriptional regulation of APP and BACE-1 [17].