Interestingly, a recent study also conducted in ADNI identified four distinct profiles of tau deposition and associated cognitive deficits to demonstrate atypical Alzheimer’s disease presentations among individuals who are primarily A+.24 Most notably, one of these four profiles comprising 19% of their sample was somewhat similar to our A−/T+ group with prominent lateral temporal tau deposition (in addition to MTL deposition) and specific deficits in language, although it should be noted that, unlike our A−/T+ group, the vast majority of individuals with this tau profile were Aβ positive. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.