In MC38 and CT26 mouse colon cancer models, Tgfbr1 knockout in CD8α+ cells released T cells from the immunosuppressive activity of TGFβ (Gunderson et al. 2020), whereas deletion of Tgfbr2 had no effect on tumor outgrowth in either MC38 or MMTV-PyMT mouse mammary tumor models (Li et al. 2020), possibly highlighting a difference between TGFβR1 and TGFBR2 signaling blockade in CD8+ T cells. Here, TGFBR2 is linked to colonic neoplasm.