TGFβ-mediated downregulation of MHC-I on tumor cells by TGFβ (David et al. 2017, Dodagatta-Marri et al. 2019, Desbois et al. 2020) may contribute to immune exclusion, although whether this phenomenon affects the structural organization of the tumor remains to be shown. Here, TGFB1 is linked to neoplasm.