CD4 and neoplasm: Importantly, Itgb8 expression in intratumoral Tregs was elevated three- to sixfold compared to that in Tregs of other lymphoid tissue, and deletion of Itgb8 in T cells using a Cd4-Cre transgene in a transplantable syngeneic prostate tumor model was as effective as, and redundant with, administration of anti–integrin β8 antibodies in delaying tumor outgrowth and extending life (Dodagatta-Marri et al. 2021).