Using tumor lines expressing different integrin β8 levels, and by manipulating tumor cell Itgb8 expression genetically, the researchers found that Treg infiltration in vivo correlates with tumor cell expression of integrin β8, inferring that integrin β8 on tumor cells leads to TGFβ-induced Treg differentiation that contributed to immune-excluded tumors (Seed et al. 2021). The gene discussed is TGFB1; the disease is neoplasm.