In a separate study, Itgb8 expression was deleted in CD4+ Tregs using a Foxp3-Cre transgene, leading to dramatic reduction in outgrowth of implanted E0117 mammary tumor cells, validating the concept that activation of TGFβ by integrin β8 expressed on Tregs is a critical component of the TGFβ-mediated immunosuppressive machinery in the tumor (Laine et al. 2021). Here, CD4 is linked to neoplasm.