In a panel of six independent chemically induced SCCs, all driven by mutant KRas and derived from the same FVB inbred mouse strain, only two with the highest nonsynonymous single-nucleotide TML showed tumor growth inhibition (TGI) to anti-TGFβ, anti-PD-1 monotherapy, or a combination thereof, whereas lower-TML tumors were unresponsive (Dodagatta-Marri et al. 2019). This evidence concerns the gene PDCD1 and neoplasm.