CD4 and neoplasm: This upregulation of CXCR3 on CD8+ T cells enhanced their migration toward the IFNγ-inducible ligands CXCL9, -10, and -11 to stimulate trafficking into the tumor (Gunderson et al. 2020), and presumably also increased trafficking of CD4+ T and NK cells, which are also regulated by this mechanism (Nagarsheth et al. 2017).