Also, NOTCH3 expression was independent of prognostic factors for PFS in adult glioma (in Table 6). In conclusion, we analyzed that the independent factors which can predict short OS and PFS in the adult glioma cohort were >50 years old, frontal location, recurrence, tumor total resection, WHO grade IV, Ki-67 expression >5%, IDH1 expression, and ATRX expression. Here, NOTCH3 is linked to central nervous system cancer.