The oncogenic function of NOTCH3 has been documented in esophageal cancer [12], ovarian cancer [13], hepatocellular carcinoma [14], and so on. Furthermore, it has been proven that cross-regulation between EGFR and NOTCH3 has long been detected in genetic studies and that, depending on the cellular context, it can be both cooperative and antagonistic [15]. The gene discussed is NOTCH3; the disease is esophageal cancer.