Rh: Rhesus factor, L/S ratio: Lecithin/ Sphingomyelin ratio, TORCH infections: Toxoplasmosis, Other (syphilis, varicella-zoster, parvovirus B19), Rubella, Cytomegalovirus and Herpes infections, MSAFP: Maternal serum alpha-fetoprotein, PAPP-A: Pregnancy-associated plasma protein A, IUGR: Intrauterine growth restriction, SGA: Small for gestational age, cffDNA: Cell-free foetal DNA, USG: Ultrasonography, CRL: Crown-rump length, MSD: Musculoskeletal disorders. This evidence concerns the gene PAPPA and musculoskeletal system disorder.