Diuretics (P˂0,001), mineralocorticoid receptor antagonists (MRA) (P= 0.01), CCBs (P˂0.001), ARBs (P ˂0.001), β-blockers (P˂0.001), and vasodilators (P˂0.001) were used more frequently in patients with resistant hypertension compared to controlled hypertension. This evidence concerns the gene NR3C2 and hypertensive disorder.