CKD: Chronic kidney disease; IHD: Ischemic heart disease; OSA: Obstructive sleep apnea; ACEi: Angiotensin-converting enzyme inhibitors; ARB: Angiotensin receptor blocker; CCBs: Calcium channel blockers; MRA: Mineralocorticoid receptor antagonist; NSAIDs: Non-steroidal anti-inflammatory drugs. This evidence concerns the gene ACE and obstructive sleep apnea syndrome.