Results of various experimental and clinical studies conducted in the past showed a strong association between raised serum CRP levels with more risk of development of ischemic heart disease, type 2 diabetes mellitus, neurodegenerative diseases like Parkinsonism, Alzheimer’s disease, hemorrhagic as well as ischemic stroke, autoimmune diseases like systemic sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. The gene discussed is CRP; the disease is systemic sclerosis.