Results of various experimental and clinical studies conducted in the past showed a strong association between raised serum CRP levels with more risk of development of ischemic heart disease, type 2 diabetes mellitus, neurodegenerative diseases like Parkinsonism, Alzheimer’s disease, hemorrhagic as well as ischemic stroke, autoimmune diseases like systemic sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. This evidence concerns the gene CRP and coronary artery disorder.