The two isoforms of CRP are involved in the process of atherosclerosis: the pentameric CRP (pCRP) isoform attaches to the phosphatidylcholine present on the surface of apoptotic cells and starts inflammation [35], while monomeric (mCRP) modulates platelet function and promotes thrombosis inside the lumen of the vessels by stimulating platelet aggregation (Figure 1) [36,37]. The gene discussed is CRP; the disease is atherosclerosis.