CD40LG and Lyme disease: C-reactive protein (CRP) was elevated in eight of 98 patients (8.2%) with a mean value of 21.9 ± 10.1 mg/dl (Table 2). We found an acute infection with pathologically elevated leukocytes and/or C-reactive protein (CRP) levels, and/or positive Immunoglobulin M (IgM) levels for acute Lyme disease (LD, neuroborreliosis was ruled out by neurologic examination), herpes simplex (HSV) or cytomegalovirus (CMV) in 42 of 98 patients (42.9%).