The genes implicated in causation, modification of risk, or progression of ALS are SOD1, ALS2, SETX, SPGI1, FUS, VAPB, ANG, TARDBP, FIG4, OPTN, ATXN2, C9orf72 [10] and VCP, Arg487, and UBQLN2. The gene discussed is OPTN; the disease is amyotrophic lateral sclerosis.