Accordingly, repstress score positively correlated with APOBEC3B expression in breast cancer, lung adenocarcinoma, and acute myeloid leukemia, malignancies wherein APOBEC3B is upregulated and plays a key role in mutagenesis (ref. 70; Fig. 4J–L). The gene discussed is APOBEC3B; the disease is acute myeloid leukemia.