According to a growing body of evidence, STAT3 is an important molecule involved in tumorigenesis and tumor development, as well as the occurrence of chemoresistance and radioresistance via the transcriptional regulation of several apoptosis- and autophagy-related genes, such as members of the Bcl2 family (including Bcl-xL).42 The gene discussed is BCL2L1; the disease is neoplasm.