Panx3 protein might have been detected in low amounts in mouse liver (Penuela et al., 2007[48]), while Panx2 protein expression has only been detected in rat hepatocytes and cultured human HCC cells, so far (Bruzzone et al., 2003[6]; Li et al., 2008[32]; Xie et al., 2015[63]). Here, PANX2 is linked to hepatocellular carcinoma.