PANX2 and Familial prostate cancer: Panx2 has been associated with breast cancer metastasis, clear renal cell carcinoma, prostate cancer or cholangiocarcinoma (Kim et al., 2019[27]; Liao et al., 2020[33]; Liu et al., 2019[34]; Qian et al., 2021[51]), while in liver it has been postulated as a tumor suppressor in vitro (Xie et al., 2015[63]).