In this respect, Cx32 and Cx26 protein levels are significantly downregulated in vivo in acute liver injury and cholestasis, while Cx43 levels increase (Cooreman et al., 2020[10]; Fallon et al., 1995[15]; Gonzalez et al., 2002[20]; Maes et al., 2016[37]; Sáez et al., 1997[53]). Here, GJA1 is linked to cholestasis.