Additionally, Panx1 is involved in inflammation during acute and chronic liver disease, such as non-alcoholic steatohepatitis and hepatitis C, and inhibition of its channels leads to alleviation of acetaminophen-induced cytotoxicity in vivo (Ganz et al., 2011[19]; Kim et al., 2021[28]; Maes et al., 2017[38]; Willebrords et al., 2018[60]). This evidence concerns the gene PANX1 and metabolic dysfunction-associated steatohepatitis.