Furthermore, according to Wolfrum et al., in an analysis of the protective effect of TNFαIP3 (A20) on atherosclerosis in apolipoprotein E-deficient mice, A20 reduced atherosclerosis by lowering the NF-κB activity through reducing the expression of NF-κB target genes, thereby modulating the proinflammatory condition associated with lesion growth (Wolfrum et al., 2007[39]). Here, APOE is linked to atherosclerosis.