Overexpression of miRNA‐146a/miRNA‐155 and miR‐150‐5p/miR‐222‐3pstimulate Th1 response in OLP in encounter to an unknown autoantigen and manifest the imbalance of Th1/Th2 cytokines like IFN‐γ production and also associate with tumor progression and lymph node metastasis. This evidence concerns the gene IFNG and neoplasm.