The miR‐146a overexpressed in oral cancer and enhance tumorigenesis and also it associate with downregulation of NUMB endocytic adapter protein (NUMB), the IL‐1 receptor associated with kinase 1 (IRAK1), and TNF receptor‐associated factor 6 (TRAF6) (Table 4).41 The gene discussed is IRAK1; the disease is lip and oral cavity carcinoma.