The main causes of POI in most women are still unknown;however, genetic reasons (chromosomal abnormalities and gene mutations), infections,and metabolic and autoimmunity disorders are associated with developing POI (3, 4).This condition is clinically characterized by amenorrhea, decreased levels ofestradiol (E2) and anti-Mullerian hormone (AMH); and an increased level ofluteinizing hormone (LH) and follicle-stimulating hormone (FSH). This evidence concerns the gene AMH and amenorrhea.