As shown in Fig. 5i and Supplementary Fig. S18, there are obviously damaged cyrpts (U-shaped structures), goblet cell (goblet-shaped) loss and tumor protrusion on the glands of the colon along with the intense infiltration of mucosa in the Control, MR+MH and MRT+Antibiotic+MH groups, while these pathological phenomena of colon tissues are almost absent in the MRT+MH-treated group. This evidence concerns the gene NR3C2 and neoplasm.