It was previously believed that blocking MHC-II with an APL was enough to prevent autoimmune disease; however, blocking of MHC alone is nonspecific and could lead to suppression of other immune responses (i.e., innate and humoral responses).81, 97 Because TCR genes are highly conserved, even between different rodent species, TCRs could be a better target for more specific autoimmune therapies.98–100 In addition, another important characteristic of T cells is that they can recognize multiple ligands. This evidence concerns the gene HLA-C and autoimmune disease.