Inhibition of ICAM-1/LFA-1 interactions (Signal-2) by antibodies, peptides, and small molecules modulates T-cell activation to suppress T1D,40, 41 psoriasis,42, 43 RA,44, 45 and allograft rejection46, 47 in animal models (Figure 3D). The gene discussed is ICAM1; the disease is psoriasis.