IL10 and autoimmune disease: Yu et al. showed that suppression of autoimmune diseases cannot be done without the presence of Tregs.67 Furthermore, the upregulation of Tregs was able to suppress EAE in an antigen-restricted manner.67 Treg cell proliferation has been associated with the upregulation of regulatory cytokines such as IL-10, IL-35, and TGF-β as well as FoxP3 and CD25 markers on T cells.68, 69 IL-10 reduces the BBB’s disruption and leakiness in MS and decreases CNS infiltration of proinflammatory molecules and immune cells through the BBB.