Due to antigen specificity, the MOG peptide can only suppress MOG-stimulated EAE, not PLP-stimulated EAE or MBP-stimulated EAE.66 Due to the antigenic specificity of this approach, it may be necessary to administer a mixture of multiple antigenic peptides for a more robust regulatory response to suppress MS.58 This evidence concerns the gene MOG and myeloid sarcoma.