IL1B and fibrosis: Further analysis revealed that the main bioactive compounds contained within the cytokine-related pathways (IL-15 production, LPS/IL-1 Mediated Inhibition of RXR Function) (Fig. 7), oxidative stress response pathways (NRF2-mediated Oxidative Stress Response, HIF1α Signaling), pulmonary related signaling pathways (Pulmonary Fibrosis Idiopathic Signaling Pathway, Pulmonary Healing Signaling Pathway) (Figs. 4, –6).