Large amounts of hypoxia mechanisms on promoting PDAC cell progression have been illuminated, containing crosstalk between hypoxia‐sensing ULK1/2 and YAP‐driven glycolysis, HIF‐1α/Notch signaling pathway and noncoding RNA‐related signaling, etc.7, 8, 9According to these studies, OSA may contribute to the aggressive phenotype of PDAC. This evidence concerns the gene HIF1A and obstructive sleep apnea syndrome.