miR-204 may affect the proliferation and apoptosis of Rb cells, thereby affecting the development of Rb, which may become an early stage molecular indicator for diagnosing and evaluating the prognosis of Rb [43], [44], [45]; miR-338-5p is up-regulated in the serum of patients with Rb, which may play a role in promoting cancer in the occurrence and development of Rb, and has the potential value of the early diagnosis of Rb [46], [47]. Here, RB1 is linked to cancer.