GDM, Gestational diabetes mellitus;<br>PE, Preeclampsia;<br>ICP, Intrahepatic cholestasis of pregnancy;<br>Bas, bile acid;<br>FXR, Farnesoid X receptor;<br>TGR5, Takeda G-proteinreceptor 5(TGR5);<br>OR, odds ratio;<br>S1PR2, Sphingosine-1-phosphate receptor 2. The gene discussed is S1PR2; the disease is gestational diabetes.