According to the latest classification criteria for the diagnosis of the APS [8], [9], the presence of aPL Abs (i.e. the IgG and/or the IgM isotype of the anticardiolipin (aCL) and/or the IgG and/or the IgM isotype of the anti-β2 glycoprotein I (β2gpI) Abs) must be present at medium to high titers in two or more occasions, at least twelve weeks apart. This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.