However, CTSA was overexpressed in CESC, CHOL, COAD, ESCA, HNSC, KICH, LAML, LUAD, LUSC, READ, STAD, THCA, UCS were less expressed , the expression of CTSA was significantly higher in glioma tissues than in paraneoplastic tissues, which expressed that CSTA was upregulated in glioma tissues, implying that CSTA may play an important regulatory role in the progression of glioma. Here, CSTA is linked to central nervous system cancer.