While the study showed that ddPCR analysis of BRAF V600E in the blood of patients with brain tumors is feasible (80% sensitivity [4/5 BRAF MT patients] with 100% specificity [0/4 patients had detectable BRAF mutation]), the number of primary brain tumors is quite small with the majority of the patients having widely metastatic disease. This evidence concerns the gene BRAF and metastatic neoplasm.