Immune-related genes, including CD4, CCL5, IFN-γ, STAT1, APOBEC3G, CD45, and ICAM-1, in PBMCs act a key role in immune responses against HIV-1 infection, and could, hence, be correlated with CD4 T cell depletion in HIV-1 pathogenesis[10]. Here, CD4 is linked to HIV-1 infection.