TAM normally associate to bad prognosis as they are “educated” by tumor-derived factors (e.g., TGF-β, VEGF, M-CSF, IL-10) to exhibit anti-inflammatory, immunosuppressive, and pro-tumoral functions, lastly contributing to tumor progression, metastasis, and even resistance to chemotherapy, radiotherapy, and immunotherapy [2, 10]. Here, TGFB1 is linked to neoplasm.