Yong et al. report that sodium butyrate improves hypertension and proteinuria in PE rats and found that sodium butyrate alleviates PE symptoms by decreasing placental antiangiogenic factors (sFlt1 and soluble endoglin [sEng]) and increasing angiogenic factors (placental growth factor [PLGF]), while reducing placental and intestinal inflammation [63]. This evidence concerns the gene PGF and hypertensive disorder.