Furthermore, we analyzed the protein levels of SGOL2 in HCC and matched adjacent non-tumor tissues in cohort 2 by Western blots and found that SGOL2 expression was extremely upregulated in HCC (Fig. 1C), and immunohistochemistry (IHC) staining from the two independent HCC cohorts confirmed the results (Fig. 1D-F). Here, SGO2 is linked to neoplasm.