SGO2 and hepatocellular carcinoma: Altogether, these data collectively verified that SGOL2, binding with MAD2 and forming a SGOL2-MAD2 complex, regulated MAD2 and then fueled tumor cell growth by dysregulating the cell cycle process, which finally promoted the malignant behaviors of HCC cells, including proliferation, migration, invasion, stemness and EMT (Fig. 8J).