NF2 and neoplasm: We postulate that a potential explanation for the enrichment of NF2 alterations and unfavorable histologic features among the epithelioid tumors in the established models compared to the previously described incidence in larger datasets may be at least partially due to a selective growth advantage related to a more aggressive tumor phenotype due to a combination of pathologic features and higher risk genomic alterations as extrapolated from OncoCast-MPM which defined high risk groups integrating multifactorial parameters including enrichment of NF2 alterations [32].