Based on tumor-infiltrated immune cells, we further explored the distribution of TMPRSS4 expression across immune subtypes and revealed that there was a significantly decreased TMPRSS4 in the lymphocyte-depleted subtype when compared to the other subtypes (wound healing, IFN-gamma dominant, inflammatory, immunologically quiet, TGF-β dominant) (Fig. 4C). Here, TGFB1 is linked to neoplasm.