In this study, we determined the levels of serum CTRP9 and different APN multimers in patients of different stroke stages and non-stroke subjects, to define the association of CTRP9/APN multimer levels, as well as dynamic changes after onset, with ischemic stroke, therefore to explore their potentials as risk factors and/or biomarkers. The gene discussed is C1QTNF9; the disease is Stroke.