The effect of FBX was tested using transgenic animals expressing Tau (WT4R) in the nerve (tmIs390 [Punc-119::WT4R, Pges-1::EGFP]) as a model for Alzheimer’s disease, which is said to account for approximately 70% of dementia. This evidence concerns the gene FBXO7 and early-onset autosomal dominant Alzheimer disease.