For example, a recent study showed that the splicing regulator ESRP2 is repressed in Wilms’ tumors by DNA methylation from their very early stages (nephrogenic rests)50, and that over-expression of ESRP2 in Wilms’ tumor cell lines inhibits their proliferation both in-vitro and in-vivo. This evidence concerns the gene ESRP2 and Wilms tumor.