The present study demonstrates that the pTyr proteome of the heart is altered in proteins related to cardiomyopathies, serine/threonine, and tyrosine kinases in two pathogenetically-unrelated models of hypertrophy cardiomyopathy (HCM), namely cardiac-specific overexpression of ErbB2 and allelic expression of R403Q-αMyHC. Here, ERBB2 is linked to cardiomyopathy.