For validation, we performed real-time quantitative PCR in our extended cohort of 13 KMT2A-rearranged infant ALL cellular models on three genes, MMP15, BAIAP3 and CD82, confirming significant upregulation of these genes via hypomethylation following treatment with decitabine (Supplementary Fig. 6F). The gene discussed is CD82; the disease is acute lymphoblastic leukemia.