We also demonstrated that 17 CVD risk factor-CpGs were associated with coronary artery disease (Table 3; corresponding P < 3.9e−5), e.g., at cg08129017 (SREBF1; reported as associated with BMI and triglyceride in the EWAS catalog) and cg02050917 (SKI; BMI-associated CpG), higher methylation levels were associated increased CVD risk, MR effect size: 1.81 ± 0.25; P = 5e−13 and 2.65 ± 0.39, P = 1.4e−11, respectively. Here, SREBF1 is linked to coronary artery disorder.