For example, when Cenci et al. assessed 14 patients with AGHD every 3 months for 5 years, they found that fasting glucose, insulin levels and insulin resistance did not change and that, despite an initial increase in frequency of abnormal glucose tolerance, mean 2-h oral glucose tolerance test glucose levels decreased between years 4 and 5 [26]. The gene discussed is INS; the disease is Insulin resistance.