The scRNA-seq DEGs combined with TLDA validation identified 24 genes significantly upregulated in the SORs, including CCND1, JUNB, BCL2, CD53, CD320, and RACK1. CCND1 is overexpressed in t(11;14) MM by rearrangement and in the majority of hyperdiploid MM by other mechanisms; however, prognostic or treatment predictive values of t(11;14) remain uncertain32. The gene discussed is CD53; the disease is Miyoshi myopathy.