In addition to the MM driver genes (e.g., CCND1, LAMP5, and TNFRSF17)19 and quadruple therapy resistance genes (e.g., NPM1 and MYC)22, we discovered upregulated DEGs in SORs (e.g., MS4A1, RACK1, UQCRH, and SQSTM1). Here, LAMP5 is linked to Miyoshi myopathy.