Moreover, although CCL2-increased extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation is correlated with LPS/TLR signaling that results in inflammatory responses of MoMФs87, CCR2-positive proinflammatory M1 MoMФs undergo the M2 phenotypic transition in liver fibrosis mediated through the CCL2/CCR2 axis35. Here, MAPK3 is linked to Hepatic fibrosis.