Consistently, loss of SHP-2 in BMDMs induces decreases in M1 macrophage-related gene expression (iNOS, IL-6, and TNF-α) and increases in M2 macrophage-related gene expression [Arg1, Fizz1, Ym-1, and IL-10] to promote M2 polarization of TAMs in the tumor microenvironment81. The gene discussed is IL6; the disease is neoplasm.